Structural basis of FimH adhesin allosteric regulation
Nature Microbiology, 2024
Read Abstract →Exploring the molecular mechanisms of microbial adhesion and host-pathogen interactions
Adhesins are cell-surface proteins or glycoproteins that enable bacteria to adhere to host cells and surfaces. These critical virulence factors play a fundamental role in bacterial colonization and the initiation of infections.
Complex protein structures including fimbriae, pili, and non-fimbrial adhesins that recognize specific host receptors.
Different bacterial species express unique adhesins targeting specific tissues and cell types in the host organism.
Understanding adhesins is crucial for developing anti-adhesion therapies and novel antimicrobial strategies.
FimH-mediated adhesion in uropathogenic E. coli and its role in urinary tract infections.
Learn More →PapG adhesins and their interaction with Gal-Gal receptors in kidney epithelial cells.
Learn More →Role of adhesins in initial bacterial attachment and biofilm development on biotic and abiotic surfaces.
Learn More →Development of compounds that block adhesin-receptor interactions as alternatives to antibiotics.
Learn More →Nature Microbiology, 2024
Read Abstract →Journal of Antimicrobial Chemotherapy, 2024
Read Abstract →Molecular Microbiology, 2024
Read Abstract →Standardized protocols for adhesin purification, characterization, and functional assays.
Access ProtocolsCurated database of known adhesins, their structures, and host receptor specificities.
Browse DatabaseBioinformatics tools for adhesin prediction, structure modeling, and interaction analysis.
Use ToolsLectures, tutorials, and review articles for students and researchers new to the field.
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